By W. K. Lelbach, H. J. Marsteller (auth.), P. Frick, G.-A. von Harnack, K. Kochsiek, G. A. Martini, A. Prader (eds.)
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Failures are tricky to regulate for lots of purposes: the immediacy of the development, significance of the development, loss of evidence-based practices, and the constrained usefulness of many constructed protocols. for this reason, combining educational methods with sensible and functional techniques remains to be an underdeveloped point of catastrophe texts.
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Additional info for Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics
1977; Kistler et al. 1977; Russell et al. 1973, 1974). Storage of vitamin A in hepatocytes and one type offat storing, nonphagocytic perisinusoidal cells [Ito cells (Ito andNemoto 1952)] could be demonstrated by fluorescence microscopy. Stimulation and proliferation of Ito cells, which are probably fibroblast precursors (Popper and Udenfriend 1970; Schnack et al. 1967), provokes an increase in basement·membrane-like material and collagen within the perisinusoidal space and leads to perisinusoidal fibrosis with partial obliteration of Disse's spaces and the sinusoidal lumen (Hruban et al.
Alkylation of nucleic acids, however, cannot at present be excluded as the mechanism for VCM-induced carcinogenesis after repeated exposure and, above all, in the target cells rather than the hepatocytes. This aspect carries on to an unresolved problem on which future experimental work will have to focus. Although the site of formation of the active metabolite is the endoplasmic reticulum of the hepatocyte, the liver cell itself is not particularly susceptible to VCM-induced toxicity. Acute hepatocellular injury has not been observed morphologically after exposure to VCM unless pretreatment with potent inducers of the mixed function oxidase system had preceded the exposure; in pretreated rats centrolobular, midzonal and panlobular hepatocellular vacuolization and even necrosis was found (Jaeger et al.
She pointed out that their reversible character might serve to distinguish the lesions from similar defects seen in vibration trauma. In retrospect, Smirnova's observations are the earliest descriptions of the full range of symptoms which much later became known as 'the syndrome of occupational acroosteolysis'. In 1963 Suciu et a1. K. J. Marsteller VCM intoxication. During a 4-year period, they examined 168 mostly young workers from two Rumanian PVC-producing plants who had not previously been employed in other industries.