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Drug Induced and Iatrogenic Lung Disease (Hodder Arnold by Philippe Camus, Edward Rosenow

By Philippe Camus, Edward Rosenow

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Tournel G, Cauffiez C, Leclerc J, et al. CYP2F1 genetic polymorphism: identification of interethnic variations. Xenobiotica 2007;37:1433–8. 3 Imaging of drug-induced lung disease THOMAS E HARTMAN INTRODUCTION Chronic and acute lung disease caused by pulmonary drug toxicity is increasingly being diagnosed. 2–7 Early recognition of pulmonary drug toxicity is important because undiagnosed injury can be progressive and fatal whereas cessation of therapy can result in reversal of the lung injury. However, recognition of drug-induced lung disease can be difficult because the clinical manifestations are usually non-specific.

Bronchiolitis obliterans organizing pneumonia: CT features in 14 patients. Am J Roentgenol 1990;154:983–7. 20. Glasier CM, Siegel JJ. Multiple pulmonary nodules: unusual manifestation of bleomycin toxicity. Am J Roentgenol 1981;137:155–6. 21. Pietra GG. Pathologic mechanisms of drug-induced lung disorders. J Thorac Imaging 1991;6:1–7. 22. Souza CA, Muller NL, Johkoh T, Akira M. Drug-induced eosinophilic pneumonia: high-resolution CT findings in 14 patients. Am J Roentgenol 2006;186:368–73. 23. Primack SL, Miller RR, Muller NL.

In the studies described herein, the compounds dichloroethylene and vinyl carbamate have been used as surrogates for chemical or drug exposures. Both are small molecules with double bonds that readily undergo oxidation by P450 enzymes to produce epoxides. The epoxides of dichloroethylene and vinyl carbamate are short-lived, are highly reactive and bind to cellular constituents including proteins and nucleic acids. The dichloroethylene epoxide 20 Mechanisms of chemically induced respiratory toxicities targets cellular proteins at the site of formation and causes acute Clara cell necrosis.

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