By Jeffrey Raizer, Andrew Parsa
This ebook stories the numerous advances in our realizing of glioma biology which were completed in the past decade and describes intimately the consequent new ways to remedy. advancements in surgical strategies, radiation treatment, and chemotherapy are comprehensively lined, with dialogue in their effect in reducing sufferer morbidity and extending survival. moreover, person chapters are committed in particular to present remedy for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. different subject matters addressed comprise remedy of the aged sufferer, investigating rising remedies from small molecules to immunotherapy and palliative care. This well timed ebook can be a important resource of up to date info for practitioners and also will be of curiosity to researchers.
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Extra resources for Current Understanding and Treatment of Gliomas
8715 42. Leu S, von Felten S, Frank S, Vassella E, Vajtai I, Taylor E, Schulz M, Hutter G, Hench J, Schucht P, Boulay JL, Mariani L (2013) IDH/MGMT-driven molecular classiﬁcation of lowgrade glioma is a strong predictor for long-term survival. Neuro-oncology 15(4):469–479. 1093/neuonc/nos317 43. Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, Hjelmeland AB, Rich JN (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15(6):501–513.
Shaifer CA, Huang J, Lin PC (2010) Glioblastoma cells incorporate into tumor vasculature and contribute to vascular radioresistance. Int J Cancer 127(9):2063–2075. 1002/ijc. 25249 67. Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golﬁnos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A (2012) Transforming fusions of FGFR and TACC genes in human glioblastoma.
Intravenous steroids (4 mg decadron) and preoperative antibiotics (1–2 g cefazolin) are administered. Anticonvulsants are also administered, either the patient’s home regimen or a dilantin load (15 mg/kg) if not previously on anticonvulsants. If elevated intracranial pressure is a concern, mannitol (1 g/kg) can be administered. Finally, a time-out procedure verifying patient characteristics, tumor side, surgical plan, expected blood loss, and details of the proposed mapping strategy is essential.