By Victor J. Dzau MD, Choong-Chin Liew PhD
Until eventually lately, a modest wisdom of genetics used to be greater than sufficient for the day-by-day perform of medical cardiology, yet advances in genetics and genomics are altering cardiovascular drugs in primary methods. The id of the genetic foundation of a number of sorts of dyslipidemia, high blood pressure, diabetes, cardiomyopathies, and vascular illnesses signalled the recent value of genetics in scientific medication.
In this well timed quantity, Drs. Dzau and Liew – either pioneers within the region – support cardiologists comprehend: • how cardiovascular genetics might rework the best way cardiovascular drugs is practiced • what fabric has fast relevance to the practising clinician • tips on how to comprise genetics and genomics on your perform to make sure updated sufferer care
The publication opens with introductory chapters, then discusses: • cardiovascular unmarried gene issues • cardiovascular polygenic problems • remedies and purposes
Outstanding members write on their parts of workmanship, making Cardiovascular Genetics and Genomics for the heart specialist either authoritative and finished. that will achieve a greater appreciation of the way genetics and genomics are already shaping present perform and should possibly revolutionize cardiology, glance no extra than this in charge reference.
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Example text
Selfassociation of the low density lipoprotein receptor mediated by the cytoplasmic domain. J Biol Chem 1987; 262: 16127–16134. 10 Beglova N, Blacklow SC. The LDL receptor: how acid pulls the trigger. Trends Biochem Sci 2005; 30: 309–317. 11 Gent J, Braakman I. Low-density lipoprotein receptor structure and folding. Cell Mol Life Sci 2004; 61: 2461– 2470. 12 Attie AD, Seidah NG. Dual regulation of the LDL receptor: some clarity and new questions. Cell Metab 2005; 1: 290–292. 13 Maxwell KN, Fisher EA, Breslow JL.
25 Villeger L, Abifadel M, Allard D et al. The UMD-LDLR database: additions to the software and 490 new entries to the database. Hum Mutat 2002; 20: 81–87. 26 Hobbs HH. Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolemia: Mutational analysis of a membrane protein. Annu Rev Genet 1990; 24: 133–170. qxd 4/24/07 10:10 Page 28 28 PART I Cardiovascular single gene disorders 27 Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia.
Long-term follow-up and treatment response. Arterioscler Thromb Vasc Biol 2005; 25: 2654–2660. 52 Seidah NG, Benjannet S, Wickham L et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci USA 2003; 100: 928–933. 53 Maxwell KN, Breslow JL. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci USA 2004; 101: 7100–7105.
