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Cardiovascular Drug Therapy in the Elderly by Adam Schneeweiss M.D., Gotthard Schettler M.D. (auth.)

By Adam Schneeweiss M.D., Gotthard Schettler M.D. (auth.)

Cardiovascular drug treatment has markedly stepped forward within the contemporary many years. not just have new medicines been brought to medical perform, yet new sessions of substances were constructed. whereas in 1960 the working towards cardiolo­ gist had a variety of approximately basically ten medicines, in 1987 approximately one hundred fifty medicinal drugs are mostly utilized in cardiovascular illnesses. aged sufferers, even if, often don't benefit from the complete advantage of this growth. this is able to be as a result of lack of awareness, a conservative method, or the global tendency to not test new medicinal drugs within the aged. it truly is now transparent that almost all of sufferers that might be handled in vehicle­ diovascular clinics can be, within the close to destiny, aged sufferers. Even now, aged sufferers shape approximately one-third of the sufferers with cardiovascular illnesses. those sufferers are approached, notwithstanding, in accordance with standards devel­ oped for more youthful populations. this is often although aged sufferers range from more youthful ones in such a lot elements, together with pathology, epidemiol­ ogy, pathophysiology, diagnostic method, administration, pharmacology, pharmacokinetics, rehabilitation, and supportive remedy. it's the goal of this e-book to offer to the clinician all medicinal drugs with which there's medical adventure within the aged or that may be almost certainly beneficial for the aged with cardiovascular ailments. the information are provided with no the authors taking a place. this could let the clinicians to make their very own choice and individualize therapy, vii viii Preface in line with a large information base. Comparative information are provided basically whilst particular comparative reports have been performed.

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57. Hager WD, et al: Digoxin bioavailability during quinidine administration. Clin Pharmacol Ther 30:594, 1981. 58. Ewy GA, et al: Digoxin metabolism in the elderly. Circulation 34:499, 1969. 59. Falch D: Determination of digoxin in plasma by radioimmunoassay. ] Oslo City Hosp 23:35, 1973. 60. Tsujimoto G, et al: Re-examination of digoxin dosage regimen: comparison of the proposed nomograms or formulae in elderly patients. Br] Clin Pharmacol 13:493, 1982. 61. Woods MN, Ingelfinger JA: Lack of effect of bran on digoxin absorption.

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Am Heart J 83:149, 1972. 81. Guignard C, et al: Effect of digoxin on the sensitivity of flickering light. Br J Clin Pharmacol 15:189, 1983. 82. Aronson JK: Cardiac glycosides and drugs used in dysrhythmias. In: Dukes MN (ed) Side effects of drugs. Excerpta Medica, Amsterdam, 1981. 83. Smith TW, et al: Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases. N Engl J Med 307:1357, 1982. 84. Smith TW, et al: Reversal of advanced digoxin intoxication with FAB fragments of digoxinspecific antibodies.

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