By Julius M. Cruse, Robert E. Lewis
In the eleven years for the reason that this atlas first released, the immunology box has skilled an exponential raise in details. along with the unparalleled advances in wisdom of mobile receptors and sign transduction pathways, an avalanche of recent info has been gleaned from modern study pertaining to cytokines and chemokines, with specified connection with their constitution and serve as.
<U>Visually complements Definitions within the Language of Immunology</U>
Now with greater than 1300 illustrations, Atlas of Immunology, 3rd Edition is the main thorough and updated remedy of primarily all options had to understand the complicated technological know-how of immunology.
Completely revised and elevated, this 3rd version features:
* hundreds and hundreds of recent illustrations
* new chapters – Immunophenotyping of Hematopoietic Malignances and Immunomodulators
* An accelerated bankruptcy at the historical past of immunology
* extra human CD markers
Written in a hugely readable, two-column structure, this entire reference covers a big selection of matters, with content material starting from photos of box pioneers to illustrations of molecular buildings of lately characterised mobile receptors, chemokines, and cytokines. The atlas additionally addresses the foremost histocompatability complicated molecules, immunoglobulins, hematopoietic cells in leukemia, and molecules of similar curiosity to immunologists. You won’t locate one other ebook anyplace that fits the breadth or element of illustrated immunological concepts.
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Additional info for Atlas of Immunology (3rd Edition)
He purified Avery’s broth concentrate until the components were free of nitrogen, showing that it was indeed specific soluble substance. He precipitated the preparation with antiserum and recovered the same polysaccharide. This led to extensive future investigations by Heidelberger, Goebel, Avery, and others on the specificity of naturally occurring antigens. Precipitin analyses permitted estimation of the quantities of numerous antigens in native materials without the need for tedious isolation and purification.
Because antigens played no part in the normal economy of the cell, the receptors were diverted from their normal function. Stimulated by this derangement of its normal mechanism, the cell produced excessive new receptors, of the same type as those thrown out of action. The superfluous receptors shed by the cell into the extracellular fluids constituted specific antibodies with the capacity to bind homologous antigens. Ehrlich endowed each of his receptors with a special chemical grouping, the haptophore group, which entered into chemical union with a corresponding group of the antigen, as in neutralization of a toxin by antitoxin.
Immunoglobulin structure and the genes encoding these molecules were defined. Diversity was shown to be due to the random rearrangement of numerous separate variable genes in different cells. Thus, the clonal selection theory has proved compatible with the accumulated scientific evidence. The Ehrlich side-chain theory (historical) was the first selective theory of antibody synthesis developed by Paul Ehrlich in 1900. Although elaborate in detail, the essential feature of the theory was that cells of the immune system possess the genetic capability to react to all known antigens, and that each cell on the surface bears receptors with surface haptophore side-chains.