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Approaches to the Conformational Analysis of by Roger L. Lundblad

By Roger L. Lundblad

The task of many biopharmaceutical polymers depends on conformation, and the following a number of years will see elevated curiosity within the conformational research of those polymers due to the advance of biosimilar or "follow-on" organic items. whereas a large choice of ways to research exists, discovering the main plausible ones will be a lot more uncomplicated with a consolidated reference that information the advantages and value of every method, with an emphasis on genuine effects and genuine items. Explores the starting to be position of Conformational research in evaluating general Biopharmaceuticals ways to the Conformational research of Biopharmaceuticals gathers the main helpful ideas and techniques right into a unmarried quantity, placing the best emphasis on these methods that experience confirmed the main fruitful. instead of disguise particular makes use of of ideas intimately, this booklet offers advertisement biotechnologists and researchers with the data and references they should make solid offerings in regards to the expertise they decide to use. With a good number of references that direct readers to basic resource fabric, it contains reports drawn from the gamut of present literature, overlaying actual tools, equivalent to differential scanning calorimetry, mild scanning, and analytical ultracentrifugation. It additionally addresses chemical tools, similar to hydrogen–deuterium alternate and hint labeling, besides infrared, ultraviolet, and Raman spectroscopy. Written via Roger Lundblad, a real pioneer in protein technology, this quantity provides the required details researchers have to entry whilst choosing the main reasonably priced strategy, together with: comparison of biopharmaceuticals Characterization of follow-on biologics caliber attributes of protein biopharmaceuticals Confrontational research of biopharmaceutical items With a transparent specialise in suitable advertisement biotechnology, this publication belongs at the cabinets of these critical researchers who're paving the way in which for the following new release of biopharmaceutical polymers.

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Soc. Nephrol. 3, 174–178, 2008. 13. S. , Therapeutic oligonucleotides: The state-of-the-art in purification technologies, Curr. Opin. Drug Discov. Dev. 7, 765–776, 2004. 30 Approaches to the Conformational Analysis of Biopharmaceuticals 14. , Oblimersen, BCL-2 antisense oligonucleotide—Genta, G 3139m GC 3139, Drugs R&D 8, 321–334, 2007. 15. , Recombiant-DNA-derived insulin analogues as potentially useful therapeutic agents, Trends Biotechnol. 11, 301–305, 1993. 16. , Therapeutic insulins and their large-scale manufacture, Appl.

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252. Sheshberadaran, H. , Protein antigen-monoclonal antibody contact sites investigated by limited proteolysis of monoclonal antibody-bound antigen: Protein “footprinting,” Proc. Natl. Acad. Sci. USA 85, 1–5, 1988. 253. , Limited proteolysis of recombinant human soluble interleukin-2 receptor. Identification of an interleukin-2 binding core, J. Biol. Chem. 264, 21097–21105, 1989. 254. , Limited proteolysis as a probe of the conformation and nucleic binding regions of nucleolin, Biochemistry 29, 5682–5686, 1990.

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