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Allergens and Allergen Immunotherapy by Richard F. Lockey, F. Lockey Richard, Samuel C. Bukantz,

By Richard F. Lockey, F. Lockey Richard, Samuel C. Bukantz, Jean Bousquet

Enlarged to explain greater than a decade of advances within the immunotherapy of allergic illnesses and bronchial asthma, this 3rd variation comprises the newest experiences at the mechanisms, manufacture, and standardization of varied allergen teams and their usage within the remedy of allergic diseases—containing eight new chapters detailing quite a few pharmacoeconomic, regulatory, production, management, and issues of safety bearing on new and rising immunotherapy suggestions.

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Case of periodical affection of the eyes and chest. Med Chir Trans 1819; 10:161. 16. Wyman M. Autumnal Catarrh. Cambridge, MA: Hurd and Houghton, 1872. 17. Blackley CH. Hay Fever; Its Causes, Treatment, and Effective Prevention. London: Balliere, 1880. 18. Curtis HH. The immunizing cure of hay fever. Med News 1900; 77:16. 19. Park WH. Toxin-antitoxin immunization against diphtheria. J Am Med Assoc 1922; 79:1584. 20. Portier P, Richet C. De l’action anaphylactique de certains venins. CR Soc Biol 1902; 54:170.

And Walker (Fig. 10) at the Peter Bent Brigham Hospital in Boston (38,39) and by Coca at a newly established Division of Immunology of New York Hospital (40). A variety of injectable materials became available for the treatment of allergic patients whose problems were not exclusively seasonal. 3. Botanists identified and collected pollens of regional indigenous trees, grasses, and weeds, and developed methods for aerobiological sampling to provide the information and technology essential for specific diagnosis (41–45).

The strong leadership of Cooke and the dedication of Coca provided opportunities for training, experience, and structured courses on preparation and use of allergenic vaccines (51). S. cities (52). Rapid dissemination and application of the newly developed methods for identification of specific agents of hypersensitivity and desensitization therapy for hay fever and asthma patients engendered a new set of problems and questions complicating logical approaches well into the 1940s (52). The era of grant-supported full-time institutionalbased academic and research positions in allergy and clinical immunology was then still some three to four decades away.

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