By Ivana Pantelic
The on-going ‘green’ pattern within the own care coupled with worldwide environmental matters, position natural-origin, biodegradable and skin-friendly surfactants comparable to alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, enough facts has been acquired to welcome a few sugar emulsifiers into the sector of drug dosage. Alkyl Polyglucosides provides a accomplished compendium which publications a researcher from the APG-related preformulation phases to formula processing, together with the research of varied APG-stabilized structures epidermis functionality. This e-book introduces numerous APG representatives, their merits on the subject of yes traditional surfactants, physicochemical and interfacial houses, attainable interplay with primary materials and various characterization strategies essential for the overview of colloidal structures. the 1st bankruptcy introduces alkyl polyglucosides, by way of chapters on their homes, behaviour, an outline of the patent safeguard mechanisms and directions for filing patent purposes. eventually, a end surveys foreign patent functions regarding APGs.
- introduces the sector of alkyl polyglucoside emulsifiers, directory the entire modern and newly synthesized APG emulsifiers
- provides specified details on a number of facets of APG-based constructions
- reveals power of APG-stabilized autos as potential supply structures utilizing a number of version medications and beauty actives
- includes an up to date assessment of analysis performed within the box of APGs, facilitating destiny preformulation and formula reviews for researchers
- offers a concise and functional compendium of characterization innovations
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Additional info for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
HPC Focus Surf 2008; 2: 18–22. Hill K, von Rybinski W, Stoll G, eds. Alkyl Polyglycosides: Technology, Properties and Applications. Weinheim: VCH, 1997. Hoffmann B, Platz G. Phase and aggregation behaviour of alkylglycosides. Curr Opin Colloid Interf Sci 2001; 6: 171–7. Holmberg K. Natural surfactants. Curr Opin Colloid Interface Sci 2001; 6: 148–59. Iglauer S, Wu Y, Shuler P, Yongchun T, Goddard III A. Alkyl polyglycoside surfactant–alcohol cosolvent formulations for improved oil recovery. Colloids Surf A Physicochem Eng Asp 2009; 339: 48–59.
Test samples were characterized using the techniques of polarization, ordinary light and transmission electron microscopy (PLM, OLM and TEM), small and wide-angle x-ray diffraction (SAXD and WAXD), continual and oscillatory rheology, and thermal analysis – differential scanning calorimetry (DSC) and thermogravimetry (TGA). This is the usual approach to evaluate liquid crystalline phases (Müller-Goymann, 2002; Müller-Goymann, 2004). PLM is suitable for detection of lyotropic liquid crystals (except the cubic mesophases) because liquid crystals show birefringence just like real crystals.
7(b)), and the corresponding ternary system with 20% of oil compared with pure APG emulsifier, confirming the predominant presence of lamellar gel phase within the structure, and also the synergism between lamellar liquid crystalline and lamellar gel phases. , 2013), indicating a certain percentage of water entrapped between the lamellae as interlamellar or fixed (‘depot’) water. , 2013). , 2013). Namely, it is proposed that, compared with binary systems, in ternary systems the presence of a third (oil) component results in, along with ordered lamellar gel and liquid crystalline phases within the continuous phase of the emulsion system, an additional phase of liquid crystals, organized in the form of layers surrounding the oil droplets.