By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual loss of life toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of latest medications, greater diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and educating within the box of TB. It comprises a hundred colour photos and illustrations that convey readability to the data offered. The atlas takes the bizarre technique of protecting a number of species histopathology, arguably the 1st and fairly in all likelihood the single source to take action. It offers an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal versions. The editors have compiled info that is helping TB scientists to tell apart among the gains of all significant animal versions on hand and to exploit them with their strengths and obstacles in brain. The e-book offers counsel for choosing the easiest animal model(s) to respond to particular questions and to check the efficacy of drug applicants.
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Extra info for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
PLoS Med, 2, e302. , and Wu, L. 2009. Neglected disease research and development: How much are we really spending? PLoS Med, 6, e30. L. 2007. Drugs for bad bugs: Confronting the challenges of antibacterial discovery. Nat Rev Drug Discov, 6, 29–40. , ed. 2006. Drug discovery and development: Technology in transition. Philadelphia: Churchill Livingstone Elsevier. , and Dick, T. 2010. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source dependant growth inhibitors deprived of in vivo efficacy.
Estimates suggest that about 2 million people die of TB every year. Each year sees an additional nine million new TB cases, with about 500,000 MDR-TB patients. The number of XDR-TB infections is increasing. About a third of the human population is thought to be latently infected. In other words, 2 billion people carry MTB without symptoms (and without being infectious), however being in danger of developing active TB disease. HIV coinfection, weakening the immune system, increases the chances of progression to active TB dramatically, resulting in catastrophic situations such as seen, for instance, in Africa (Donald and van Helden, 2009).
The Clara cell is a nonciliated cuboidal cell found in the membranous and respiratory bronchioles. It replaces the diminishing goblet cell population in small bronchioles. The Clara cell is dome shaped and rich with mitochondria and endoplasmic reticulum. 8). Clara cells also secrete surfactant apoproteins that decrease the surface tension and keep the small air channels open. They are also thought to regulate the transport of chloride ions. , 1992). Acini and Alveoli Several alveolar ducts result from the division of a single respiratory bronchiole.